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KMID : 0960920030020010042
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Dementia and Neurocognitive Disorders
2003 Volume.2 No. 1 p.42 ~ p.48
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Regional Cerebral Blood Flow in Patients with Transient Global Amnesia -Statistical Parametric Mapping analysis of Tc-99m ECD SPECTSeung-
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Lee Seung-Jae
Yang Dong-Won
Shon Young-Min
Kim Beum-Saeng
Chung Yong-An
Sohn Hyung-Sun
Juh Ra-Hyeong
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Abstract
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Background and Objectives: Transient global amnesia (TGA) is a clinical syndrome characterized by sudden memory loss of recent events, transient inability to retain new information, and retrograde amnesia in the absence of other neurological signs and symptoms, resolving within 24 hours. This study investigated alterations in regional cerebral blood flow (rCBF) in patients with TGA by using statistical parametric mapping 99 (SPM99).
Methods: 5 patients with TGA and 9 age-matched normal control subjects were evaluated. Tc-99m-ethyl cysteinate dimer (ECD) SPECT were performed within 1 to 4 days of the event to measure the regional CBF, and SPM99 were applied to the objective analysis of SPECT data between two groups. Follow-up ECD SPECT was done at 49 to 107 days (mean 76.8) after the previous SPECT to evaluate the long term changes of the regional CBF.
Results: The SPM analysis of SPECT images revealed significantly decreased rCBF in the left superior temporal gyrus, the left parietal supramarginal gyrus and the left thalamus (corrected p=0.01) and increased CBF in the contralateral mirror regions in patients with TGA. Follow-up SPECT showed persistent rCBF changes in the same regions.
Conclusions: We demonstrate decreased perfusion in the left cerebral hemisphere and increased perfusion in the right cerebral hemisphere in patients with TGA. This reciprocal change of rCBF might suggest that imbalanced neuronal activity between two hemispheres may be important in the pathogenesis of the TGA. Also, the abnormal rCBF changes appeared to last long after the complete recovery of clinical manifestation of TGA.
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KEYWORD
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Transient Global Amnesia, SPECT, Cerebral Blood Flow, Statistical parametric mapping (SPM)
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